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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3df3518225c8d6a6b2e71c741b3196f7bfcc3a7a8eac668312c307e610ba1a0c' 
  AND token = 'DXkxRoeZbIq/t9WEs7LAtQ0ENl61QvauRpbdDOZ2lMk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}