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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a442240d027d69f357e2c03d062122e4430cf36220f6e0b9c28b9056a6be453f' 
  AND token = 'zjVAmE6EZtCt/vYF+DrlRhI0vkkNoYZWZu8s9z1IlQI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00040

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}