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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a53ff6a9c997bdedb6651c3fd1e853cd760a8c1729d5be048e13652e53c7d5f' 
  AND token = 'IHnDS0hrrR4C+S3a6z+jiCol7kbHUbWHzLUjE2ySD2o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}