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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78644777bcadf6c6021c86bdb4f63c11d64356d29412c30b1aebc441219e1ad3' 
  AND token = 'NyfcgoYXStBlw5s7sgydplIHoG1727oD4jlBBjwIJOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}