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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4ddf7b8c20ce90996c4a9d20adece8e591654c2e62b54ff78a1dbc65ad95d729' 
  AND token = 'iT1g3rJkt1otSnTtRU+VDHrwMbQrDG3Q7R7X6ly9P24=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}