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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b37358bd6be309e46ec8ed01def8e77d8e8b1ada4d661460669dd6a70db0291' 
  AND token = 'GPLIiMj0RZKjMZK4r1Zy7S9x0w/XM18p3NFC3VtxJDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}