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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7500c9cc0f2e31d3cf8e8fff87d9a12918e6129def4524089e202f42c4f53609' 
  AND token = 'e6HnlANdHd0aq4lBlayit5lQd5Ac1luzNLD9eZZm2MI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}