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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '784b4e0522ed1bf709e061fd8c32f011cc3476aca5d1304f13ae9729f3cd3b0f' 
  AND token = 'q/x4v4N0LhDjhOnqtLrr9wwvZ1dBOioQBuOlBvE4eNg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}