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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00859f2e9d82dfd028115f9a0d596f40caa162d36f148339a94c1a5c261415bf' 
  AND token = '4mJdJWyiLlnKGgvy0zliGFLwfYIsTNWAIdTDxZwbUZA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}