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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e18173c1a6434e708e78a0066a05eb18e31071a1e2de8f8263cd85a35cf5e3f3' 
  AND token = 'g2STUyrIjHi6x1qi9e2/aBfbtVPhMfaXRqI+GDenM1Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}