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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c866a100e4cbb72968b91cb6a14d7a0737bbe5a5ae863d1ed48a721225d47eb4' 
  AND token = '/+lDMWaXIjEh2Wae+ayawVlfLAC8+AM4SuVGKb8W1uc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}