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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b6567ea665baab49d6aab94a94889a12a86c264e0d83b0a262e2196ccf682f43' 
  AND token = '+Z6akWcTKRIH/BAu0fk/CiTWP2zZLGRpUrQu6Au9QY8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}