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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22cf4af29da33f0a4e791b0f7c905e56f017e490fd640521de0a1a74715c6ca1' 
  AND token = '3nGYOTVGlzG6HPMKoAQVLterDvpeo8lYdHL6/JfnsoY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}