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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ae80429b70ec21d50d7d2b266e80191a2b6e99d8057664e6e9d0b3276fb514c1' 
  AND token = '8YcCXKiRnr480+9csuj9dzpFXc81xweTixu9zUCbFQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}