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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce2d3ee3f03b5b689594d56b059b09b66e22e1a07791652fb153552e556c335a' 
  AND token = 'B0tntFIveYcsMDgPIoAvs1GQACC+KR3c0EFSA4/WZy0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}