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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e5a6f9af8e864107d8cd40ced032d7b8e1436f71e6f29d961315d2d2ea3491a' 
  AND token = 'UxIrpj25qUFesmSznTPMwkWgpjKGxW9bDJo1QyEjbc4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}