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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5eed12a8c4897176b9fef8463367accaa3eeafe32af65e8092be741b1701e45' 
  AND token = '4TZzXIw6J7HH6f7VBEnN9tt3kkxuFbOm1PA7B4Ay7IM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}