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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b11346f844d4995a2f07f0adb060b4ab278ad5010e8de801bb5bf6ca9e19783' 
  AND token = 'R5KKaQZoGM3XGp+Y1vhplSAppk4wIC9WQ0VExhKE0hQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}