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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181524a84686d0a01e9c308ac6ecf42b6f2d9911566c29e13cb3d3293bcbc4b5' 
  AND token = 'WZV1eE0C2/j+igT4GfXIdrQB2QOaI6BJiliUNmsYBxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}