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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f321a2659d121f50edfe8697a419017abb009363be6649417888d20f2d3051f' 
  AND token = 'hPtWnGyX/zM6Mw2UIjbbtDxU0s0cIwEGn1mPHk8uimU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}