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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb48ea223afdd0e0ee93a22eb00fabc7499363c39e336e383179233e3fd9e48d' 
  AND token = 'sXtsf9rlR1eMovEiwmnfwFEf+dsMXs0GQfEUSsB8Gh8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}