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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'efa197f3db9221daaebde4fb4d19ea5a239b536ff6e4da43a9c39b2c44491a46' 
  AND token = '8P/4PPWNPg1VuF6VLOdSnjAENvFxthsfb9X8sAqinI4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}