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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5cae2eb63e2a00f32d86811192ffbdb2c8c0646841d3761a32e98acc26ccb5e1' 
  AND token = 'HPEM6YeStSf56WwmT3TJSc8EX07qvuwbh+f3L5xUjxs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}