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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78325e84c103d00dee91c5748085550fd64e7669908eca5e1ea377be8a13cfe6' 
  AND token = 'isDpRSgiwzFziRuqxwFosh8239N7U4hO5xrxQaYFAC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}