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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278cd3c7d3f4b0a068627c6fbbe1e418f30174bb87c307214003b2a07bdeb63f' 
  AND token = 'f+UubPWbjSE+PALdD8FIjEdv9kAI76vBk5ygjctTsPM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}