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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '101516bbc869eb4dc00536b3b7f53dc8a45cc3ec7940d1b8e67006f74c606656' 
  AND token = 'VMlzqg0dRAaKZL6oSnJT8SEipEeFV9ujxfvGMkOHPX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}