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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acb319999d48304ae70db844d94b6263e4bd7756e0659c2026e340765daa0387' 
  AND token = 'j+TYIwi8Zgym9K39/vcSltgoXAu9xUMTHnWQSAxCiAU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}