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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8217e37b2a944357f7cea6315d0aa43ca2d8fa552b45e63e5d0dc02dc6cf29e' 
  AND token = 'kz3CkUPnKlGbGDFOcIH37fHpp+lH9p48Yrzb1BiDpZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}