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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48b78d0a8ae7d3ea04f076e0b0d743038e39281d6c763e6b2c9bfdcb822a8022' 
  AND token = 'LOFkSMjkesJiaDw37Vy1YphEaym/VezwqeXbE4MEKPU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}