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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de1be804b886e2ef0f018d0514026fed4ccb1e3c8e20c27b324c010b89194ab6' 
  AND token = 'iVcGNsxIMTOuzEzXpG4mNHPMnvKnE3/WjjaeDB0sHMY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}