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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c21d78eb187a7f97d38d41d32473af2861ac9d97b7303baa1c659dafde620e4' 
  AND token = 'F4sma+0RBQ834EwZvNSgOVQdvOzrh2dQDRcWMXxMl1s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}