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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6fd221e92c71db33b8be9b113d13f9642354df281d27673da8e67b6d1552119f' 
  AND token = 'yb8t4z0p8xSfSW2XT7nJeGmPRUGYLASquw1IUCbtAtc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}