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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3f0ce3e0a395450a325fb0c06304da1c4e0fadc3166efb3b9fe3669f166f486' 
  AND token = '2v8xS5+iRRWyuq9X2HgLghtsyeGjWsHGT81EZR+Dgw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}