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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b0fc292fbb2c2cc95ef0686d164dd47d40208e0c3033afa7b0c352e9b6e1f26' 
  AND token = 'afSaKgy7UdQ/NhOdwHNhPbpcHGWo9GooPVFYmpfpv44=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}