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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f78e03b428f656f1a8eb88aefc208fe45a94fef97a44c629c0dcf1aea8649714' 
  AND token = 'z1b0zf9qvCy6lY2xRrdcPeQGs7OVB0EL10CE05+WH+w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}