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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '195d8c8daa8223f4481d05534c10031d428b777fc9664c77e71bfe5d089de28e' 
  AND token = 'KAc5P5i/hOGb3k50pTCGdeP1SsxRElB2sDlCuUG0xZc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}