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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '40063f196204b7050ed4064120b16069e8bb15f109ea3ca7e7b8cdfd5b82f78d' 
  AND token = 'WpOYNze4V3+/4HXqq5kOhlIhdx6/DWVe0Yaxq6k38JQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}