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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a18431804609049079c07c95ab7f58b6b5e37e12890db99918071ef783d8ef46' 
  AND token = 'yzy4X3HzjAJTSygH0LW1vIxB+ff5AftHbmHbs9qzSjU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}