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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '163d945bf410f8a4da4ed7b8b957c4603d05075ba8634b9452e08abb728d75a3' 
  AND token = 'k3vy80OmzDFJKUI0+GPFoDul5WmsFCcgHyRyFNRUKv8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}