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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '500e83bbc9fe24b8f4cb129f76a6b9a9beb2c34681f8ee79c242616e33e95683' 
  AND token = 'tlNPtcoArknofh+kZmMjMdv7IV77LOC85wyZIV5PVtQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}