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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74f9b7b213ee204845d0d5343c17133d13fb6e7830e31e9c445ef58c43583404' 
  AND token = '489ElvCnzgtloHvSp5QCBplTs8k35aItB53CqzD9EYM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}