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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f549e8218f025824e15f6fdb342afc886c4364e53419f562404b99f078463921' 
  AND token = '6TcKW+cwQ6O5Px7RoKaxiF1SCNav1WL7JcWw/wUfxaw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}