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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f279c9bddc1fd6d994912f7d4b29eb4f7430c353bcafe184929489a0f46c0f53' 
  AND token = 'nTy4/wwUlrHyE2jnWC+2sR1FyEXl1F40KsjCt6kEmvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}