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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c1bb262dbc833d3a9a575675982c5f930f1699f3b7880636b9d2f8d87b0b58' 
  AND token = 'Q1wga/UQyyshOKL/OUA/nTrg/tJUewaePuK6oRPjLMs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}