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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8474e5cad6827b8ef899b1739bd28a2f0cf065b1c4925d1a369ad2245a40c57' 
  AND token = '+MNvdNAdhjLEQLT7tDVMaUo2EKNDmazcCw8uAbe4150=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00057

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}