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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c946e38d666b76e04aed72cf1a1dc1349f1eb1b0e28bdeea9b3f94500bd8577' 
  AND token = 'ekhun6uPMw6KcCPu1sjT9aEbwpWmhXR7Uq/ojm7jT7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}