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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a37a888b3451752fe75454ee324cfe90a99b4bfae3c65c41a72671b3fc384e83' 
  AND token = 'm4Ezdtqa1secCZSrf+QXZxSehau5NEcRQzCYn4l9LYs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}