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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e21485941ee3796ab01d22430a21b3de5f0025e2d4f5d1337466a17c542f260' 
  AND token = '+YAfJk2Lw1T12FJpb4NWuTRh2UOkwD28zD8m89gtyYA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}