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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'afea41bd3fdda83f06b8d49d5a1865cdba7e085ef2900605be467e10378a21d6' 
  AND token = '21j6DIrebgnbXAyPgZO2SzdnteWaVOFB/zGBIiL0u7I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}