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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e225ed15605dcd5dcc2feb83c798a2392c1a9bd9232ed0c13bb78f32c884b69' 
  AND token = '+mXlp4966Hb7zqy52fMSeQKzdzv2jo7KcDxhgcm5/do=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}